- Advances in the Diagnosis and Treatment of Neuroblastoma
- Research for a Better Quality of Life
- SIOPE - the European Society for Paediatric Oncology - the European Society of Paediatric Oncology
To manage neuroblastoma, it is important both to see the appearance under the microscope and to assess molecular features of the tumor. In addition to the histology, amplification of the MYCN gene, DNA content, chromosomal changes, and expression of certain master genes affect the behavior of the tumor and how we treat it. Neuroblastoma Staging There is an international staging system for neuroblastoma: Stage 1 — A single tumor that is removed without any visible tumor remaining Stage 2A — A single tumor that is not completely removed, but has not spread to lymph nodes Stage 2B — A single tumor that has spread to regional lymph nodes on the same side of the body Stage 3 — An unresectable tumor that crosses the midline of the body or involving lymph nodes on the other side of the body Stage 4 — A tumor with distant spread Stage 4S — A special category for infants under 1 year old with primary tumors that do not cross the midline, with spread limited to skin, liver, and limited marrow involvement Neuroblastoma Therapy and Prognosis Neuroblastoma is classified as low, intermediate, or high risk on the basis of age, stage, and tumor biologic features.
For low-risk neuroblastoma, resection alone may be the only treatment needed. For intermediate-risk neuroblastoma, a moderate course of chemotherapy would be given in addition to surgery. For high-risk neuroblastoma, the treatment includes aggressive chemotherapy, resection, high-dose chemotherapy with stem cell rescue autologous bone marrow transplantation , treatment with cis-retinoic acid Accutane to cause maturation of the tumor, and immunotherapy.
Radiation therapy is often helpful in addition to chemotherapy and surgery. Treatment of neuroblastoma is an area of very active clinical research.
Goals include reducing side effects of treatment of intermediate-risk disease and increasing the cure rate of high-risk disease. Therapy for Relapse If neuroblastoma recurs after resection only, or after modest initial therapy, treatment may again involve surgery, radiation therapy, and chemotherapy, perhaps including autologous stem cell rescue.
Treatment of recurrent neuroblastoma is an important area of investigation. New chemotherapy agents, molecules that deliver radiation to the tumor, and immune therapies are being considered. Long-term Evaluation After treatment is complete, patients are followed for signs or symptoms of recurrent neuroblastoma and for late effects of their particular treatment. The aggressive treatment for high-risk disease can affect growth, hearing, heart and kidney function, and fertility. Patients are also at risk to develop other forms of cancer later.
Detecting and treating potential problems early is important to maximize health and the quality of survivorship. Request your next appointment through My Chart! Whether you're crossing the country or the globe, we make it easy to access world-class care at Johns Hopkins. The Allegheny Health Network collaborates on an array of initiatives that support cancer care and research.. Learn more. View our phone directory or find a patient care location. Privacy Statement. Non-Discrimination Notice. From Wikipedia, the free encyclopedia. National Cancer Institute. Archived from the original on 10 November Retrieved 9 November Retrieved 10 November World Health Organization.
Chapter 5. Archived from the original on The Lancet. Archived from the original on October 5, Retrieved Pediatric Radiology. Bibcode : Natur.
- Pediatric Oncology: Neuroblastoma;
- Hiding in the Mirror: The Quest for Alternate Realities, from Plato to String Theory (by way of Alicei n Wonderland, Einstein, and The Twilight Zone)!
- Liszt: My Travelling Circus Life;
- Natural Products-Drug Discovery and Therapeutic Medicine.
- Advances in the Diagnosis and Treatment of Neuroblastoma;
- Run for Kids with Cancer… Fintro Dwars door Mechelen.
Bibcode : Sci Lay summary — Children's Hospital of Philadelphia November 30, In Brodeur, Garrett M. Amsterdam: Elsevier. American Journal of Epidemiology. Thomas; Cohn, Susan L. Paediatric and Perinatal Epidemiology. Seminars in Nuclear Medicine. Sue; Menda, Yusuf Journal of Nuclear Medicine.
Advances in the Diagnosis and Treatment of Neuroblastoma
Journal of Clinical Oncology. New England Journal of Medicine. Updated results of the population based controlled trial in Germany". Cancer Letters. Expert Reviews in Molecular Medicine. Nature Reviews Cancer. International Journal of Cancer. Maris presentation ASCO ". Journal of Carcinogenesis. Seminars in Surgical Oncology. Bone Marrow Transplantation. Thomas; Brodeur, Garrett M.
Patrick Fevzi; London, Wendy B. Archived from the original on September 8, Journal of the National Cancer Institute. Cytogenetic and Genome Research. BMC Genomics. In Pizzo, Philip A.
- What is neuroblastoma?.
- Condition: Neuroblastoma.
- Guide for evaluation of concrete structures prior to rehabilitation.
- Neuroblastoma: Johns Hopkins Pediatric Oncology.
- Pediatric Neuroblastoma.
Principles and Practice of Pediatric Oncology 6th ed. In Cheung, Nai-Kong V. Bruce; Perrin, Eugene V. The American Journal of Pathology.
- A Basket of Trouble (Claire Hanover Mystery, Book 3)?
- Condition: Neuroblastoma.
- The Collected Writings of Samson Occom, Mohegan: Literature and Leadership in Eighteenth-Century Native America!
The Bryan College Station Eagle. April 12, Archived from the original on June 11, Gail Nature Reviews Clinical Oncology. Archived from the original on September 25, Thomas; Reynolds, C. Patrick; Seeger, Robert C. Biology of Blood and Marrow Transplantation. Elsevier BV. ICD - 10 : C Small-blue-round-cell tumors. Craniopharyngioma Pituicytoma. Astrocytoma Pilocytic astrocytoma Pleomorphic xanthoastrocytoma Subependymal giant cell astrocytoma Fibrillary astrocytoma Anaplastic astrocytoma Glioblastoma multiforme. Ependymoma Subependymoma.
Choroid plexus tumor Choroid plexus papilloma Choroid plexus carcinoma. Oligoastrocytoma Gliomatosis cerebri Gliosarcoma. Ganglioneuroma : Ganglioglioma Retinoblastoma Neurocytoma Dysembryoplastic neuroepithelial tumour Lhermitte—Duclos disease. Neuroblastoma Esthesioneuroblastoma Ganglioneuroblastoma Medulloblastoma Atypical teratoid rhabdoid tumor. Meningioma Hemangiopericytoma. Primary central nervous system lymphoma. Note: Not all brain tumors are of nervous tissue, and not all nervous tissue tumors are in the brain see brain metastasis.
Parathyroid neoplasm Adenoma Carcinoma. Pinealoma Pinealoblastoma Pineocytoma.
Research for a Better Quality of Life
Arthritis in children. Juvenile idiopathic arthritis. Inflammatory bowel disease Sarcoidosis Cystic fibrosis Autoimmune hepatitis. Acute lymphoblastic leukemia Lymphoma. Septic arthritis Osteomyelitis Tuberculosis Lyme arthritis. Osgood—Schlatter disease. Osteoid osteoma Pigmented villonodular synovitis Hemangioma.
Synovial sarcoma Rhabdomyosarcoma Ewing's sarcoma. Categories : Endocrine neoplasia Small blue round cell tumor Brain tumor Dermal and subcutaneous growths Rare cancers. Namespaces Article Talk. Views Read Edit View history.
SIOPE - the European Society for Paediatric Oncology - the European Society of Paediatric Oncology